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limk inhibitor  (Tocris)


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    Tocris limk inhibitor
    Limk Inhibitor, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 3 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/limk inhibitor/product/Tocris
    Average 92 stars, based on 3 article reviews
    limk inhibitor - by Bioz Stars, 2026-04
    92/100 stars

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    LIMK activity promotes VSMC migration. The activation of RhoA/ROCK by stimuli such as PDFG-BB leads to the phosphorylation of LIMK and inactivation of cofilin, thereby promoting actin polymerization. Concurrently, ROCK phosphorylates MLCP and inhibits its activity, resulting in increased phosphorylation of MLC and subsequent VSMC contraction. Activation of inflammatory cytokines such as CCR8, CKLF1, and CXCL12 also modulates cell migration via lamellipodia formation. These inflammatory processes likely promote VSMC migration in a LIMK-dependent manner. Whether inflammatory cytokines activate LIMK via Rac2 activation remains unknown. (PDFG-BB: Platelet derived growth factor BB; Arp 2/3: Actin related protein 2/3; CCR8: chemokine receptor-8; CKLF1: Chemokine-like factor 1; CXCL12: C-X-C motif chemokine 12; MLCP: Myosin light chain phosphatase).

    Journal: Frontiers in Physiology

    Article Title: LIM kinases in cardiovascular health and disease

    doi: 10.3389/fphys.2024.1506356

    Figure Lengend Snippet: LIMK activity promotes VSMC migration. The activation of RhoA/ROCK by stimuli such as PDFG-BB leads to the phosphorylation of LIMK and inactivation of cofilin, thereby promoting actin polymerization. Concurrently, ROCK phosphorylates MLCP and inhibits its activity, resulting in increased phosphorylation of MLC and subsequent VSMC contraction. Activation of inflammatory cytokines such as CCR8, CKLF1, and CXCL12 also modulates cell migration via lamellipodia formation. These inflammatory processes likely promote VSMC migration in a LIMK-dependent manner. Whether inflammatory cytokines activate LIMK via Rac2 activation remains unknown. (PDFG-BB: Platelet derived growth factor BB; Arp 2/3: Actin related protein 2/3; CCR8: chemokine receptor-8; CKLF1: Chemokine-like factor 1; CXCL12: C-X-C motif chemokine 12; MLCP: Myosin light chain phosphatase).

    Article Snippet: Since the first report on the development of a selective inhibitor of LIMK activity by Bristol-Myers-Squibb in 2006, only one such molecule has reached clinical trials for treating glaucoma ( ).

    Techniques: Activity Assay, Migration, Activation Assay, Phospho-proteomics, Derivative Assay

    Representative studies on the role of LIMK in cardiovascular diseases.

    Journal: Frontiers in Physiology

    Article Title: LIM kinases in cardiovascular health and disease

    doi: 10.3389/fphys.2024.1506356

    Figure Lengend Snippet: Representative studies on the role of LIMK in cardiovascular diseases.

    Article Snippet: Since the first report on the development of a selective inhibitor of LIMK activity by Bristol-Myers-Squibb in 2006, only one such molecule has reached clinical trials for treating glaucoma ( ).

    Techniques: Migration